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I-TECH Presents at ICBD 2023 Conference

Representatives from I-TECH Malawi attend ICBD 2023 in Santiago, Chile from 1-4 March 2023 to present findings from the Malawi Birth Defects Surveillance Program. L-R: Luke Chiwala, Simkonda Yamikani Malanga, George Bello. Photo Credit: I-TECH Malawi

Representatives from I-TECH Malawi attended and presented findings from the Malawi Birth Defects Surveillance Program at the 2023 International Conference on Birth Defects and Disabilities in the Developing World (ICBD 2023). ICBD 2023, hosted by the March of Dimes, took place in Santiago, Chile, from 1-4 March 2023.

The conference brought together maternal and child health practitioners and researchers from around the world who presented their latest research, tools, and approaches in surveillance, diagnosis, and care for babies born with birth defects. This year’s theme was “Accelerating Action for Birth Defects and Disabilities: Surveillance, Prevention, Diagnosis, Management and Family-Centered Care.”

The following presentations were given during the conference:

  • “Prevalence of Adverse Birth Outcomes and External Birth Defects Among Women Living with HIV in Malawi”
    Authors: Bello G, Smith-Sreen J, Williamson D, Taulo F, Kabaghe A, Kerry Thomson K, Kagoli M, Chipeta S, Namakhoma I, Nyirenda R, Babaye Y, Auld A, Kim E, Matatiyo B, Zenengeya E, Muula AS, Nyasulu I, Gomes MF, Chiwala L, Kamzati M, Mkungudza J, Valencia D, Moore C, O’Malley G, Wadonda-Kabondo AN
  • “Correct Diagnosis of Birth Defects by Health Facility Staff in Four Facilities in Malawi”
    Authors: Malanga SY, Luke Chiwala L, Kamzati M, Valencia D, Mkungudza J, Bello G, Williamson D, Moore C, Thomson K, Ireen Namakhoma I, Gondwe E, Banda F, Sangaya N, Chirwa M, Kagoli M, Chipeta S, Nyirenda R, Zenengeya E, Babaye Y, O’Malley G, Wadonda-Kabondo N, Kabaghe AN
  • “Use of Electronic Data Collection and Web-Based Portal to Ensure the Completeness, Timeliness, and Accuracy of Final External Birth Defects Diagnosis in Malawi”
    Authors: Chiwala L, Kamzati M, Valencia D, Mkungudza J, Bello G, Williamson D, Moore C, Thomson K, Namakhoma I, Gondwe E, Banda F, Sangaya N, Chirwa M, Kagoli M, Chipeta S, Nyirenda R, Zenengeya E, Babaye Y, O’Malley G, Wadonda-Kabondo N, Kabaghe AN

To learn more about ICBD 2023 conference, please visit the ICBD 2023 website and review the ICBD 2023 Agenda.

*Bolded names indicates presenting author.

I-TECH Data Presented at CROI 2023

Data from the International Training and Education Center for Health (I-TECH) program in Malawi were presented during the 2023 Conference on Retroviruses and Opportunistic Infections (CROI). The annual conference took place in Seattle, WA, from 19-22 February 2023, and brought together researchers, academics, and experts to discuss and present on their scientific achievements and new research.

During the “Insights into Prevention and Treatment of HIV in Women and Children” oral abstract session that was held on 20 February 2023, representatives from I-TECH Malawi presented on recent HIV infection surveillance data in breastfeeding women in Malawi:

The Centers for Disease Control and Prevention also presented a poster during the poster session that used data from the I-TECH Malawi HIV Recency Surveillance project:

To learn more about CROI, download conference resources, or to peruse the 2023 CROI program, please visit the CROI 2023 website.

Note: Bold name indicates presenting author.

 

Julianne Meisner

Julianne Meisner, PHD, MS, BVM&S, is an epidemiologist, veterinarian, and Assistant Professor in the Department of Global Health at the University of Washington (UW), researching issues related to One Health and pandemics. Her work focuses on human health at the human-animal-environment interface, with an emphasis on novel pathogen emergence, the human health effects of livestock keeping, and anticolonial approaches to global One Health research. She has many years of experience conducting linked human-animal research among livestock-keeping communities in sub-Saharan Africa, and strong teaching and research interests in epidemiologic methods and biostatistics, in particular spatial epidemiology and methods for drawing causal inference from observational studies. She holds her veterinary degree from the University of Edinburgh, and her MS and PhD in Epidemiology from UW.

Her current projects focus on novel virus emergence at high-risk human-animal interfaces in South America, Africa, and Asia, and the role of land use change in disease emergence; methods for modeling human-animal contact networks for more accurate modeling of disease transmission between animals and humans; the role of land tenure and land rights in human and animal health; and One Health surveillance system strengthening.

Program Highlights

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Creating a Data Warehouse to Support COVID-19 Surveillance in Mauritius

The Digital Initiatives Group at I-TECH (DIGI) worked closely with the Mauritius Ministry of Health and Wellness (MOHW) to implement a national laboratory information system (LIMS) using OpenELIS and expanded it to create a national-level data warehouse.

The data warehouse captures all the information that has been input into OpenELIS by the two reference labs and all ten regional flu clinics and creates real-time, easy-to-read data dashboards. These dashboards are used by the MOHW staff and public health officials to track national COVID-19 cases numbers and trace ongoing and potential outbreaks of COVID-19 and other infectious diseases.

DIGI continues to support MOHW with LIMS training, LIMS maintenance, and national laboratory strengthening.

Implementing a National Laboratory Information System in Mauritius

Since 2020, the Digital Initiative Group at I-TECH (DIGI)  has worked closely with the Mauritius Ministry of Health and Wellness (MOHW) to deploy a national laboratory information management system (LIMS) using the OpenELIS platform. The LIMS connects the national reference laboratory to regional laboratories and flu clinics around the country to quickly process COVID-19 tests, as well as send results notifications to patients via text message or email.

The OpenELIS system, while implemented to support COVID-19 surveillance, was also designed to be able to support most routine lab workflows, including HIV viral load testing and other other infectious diseases (e.g., HIV, Ebola, Zika, Chikungunya), which ensures MOHW can quickly trace, respond to, and manage cases.

DIGI continues to support MOHW with LIMS training, LIMS maintenance, and national laboratory strengthening.

Birth Defects Surveillance in Malawi

Malawi is one of first countries in Southeast Africa to respond to the World Health Organization’s call for robust birth surveillance systems. Routine surveillance is essential for public health monitoring of pregnancy outcomes and birth defects, especially in high-HIV burden settings where women living with HIV initiate the use of antiretroviral therapy before or during pregnancy.

Since 2016, the International Training and Education Center for Health, in collaboration with the Centers for Disease Control and Prevention, has supported the implementation of an active hospital-based birth surveillance system at four high-volume facilities in Malawi. To date, a total of 165,608 of births have been assessed. A subset of women are also enrolled in an ongoing nested case control study to assess associations between external birth defects and maternal exposures such as prior health conditions, medications, and environmental and lifestyle factors.

Anticipated use of these data include:

  • Establish a baseline prevalence of external birth defects in Malawi
  • Evaluate the impact of introducing new drugs for the management of HIV (e.g., dolutegravir) on the prevalence of external birth defects
  • Advocate for investment in programs and interventions to reduce the occurrence of birth defects and adverse pregnancy outcomes.

National COVID-19 Emergency Response in Malawi

In collaboration with the Malawi Ministry of Health (MOH) and Centers for the Disease Control and Prevention (CDC), I-TECH has supported the national COVID-19 response in Malawi since March 2020. Technical assistance has focused on laboratory capacity, supporting quality COVID-19 surveillance and data management, and implementing a COVID-19 population-based survey with oversight from the Public Health Institute of Malawi (PHIM), under MOH.

In June 2020, I-TECH seconded a Technical Advisor (TA) to PHIM to support COVID-19 activities. The I-TECH TA acts as secretariat for the national Public Health Emergency Operations Center (PHEOC), supporting the coordination of the multi-sectoral COVID-19 response, developing and revising strategies and procedures, facilitating communication, and ensuring access to and sharing of COVID-19 data and information between partners.

I-TECH has also assisted with data management and reporting at the district level, as well as with contact tracing and adherence to infection prevention and control measures.

I-TECH has been able to leverage use of its platform for HIV laboratory activities to provide critical lab support for COVID-19 activities and provide key support to the National Health Reference Laboratory, focusing on building or increasing laboratory capacity including with genomic sequencing, maintaining quality assurance, and improving communication and coordination among laboratory stakeholders.

The I-TECH Team also coordinated a population-based survey to evaluate the extent of spread of COVID-19 in five high-burden districts in Malawi.

I-TECH Presents Posters at IAS 2021 Conference on HIV Science

The International AIDS Society (IAS) virtually hosted the 11th Conference on HIV Science on 18-21 July 2021. The conference also included a “local partner hub” in Berlin, the original host city, for local experts to gather in person. This biennial conference brings together top HIV researchers, experts, and scientists for presentations and discussions on the latest advances in HIV research and practice.

Representatives from the International Training and Education Center for Health (I-TECH) virtually presented the following posters:

Representatives from I-TECH’s partner network organizations and the Centers for Disease Control and Prevention (CDC) also presented data from I-TECH-supported programs in Malawi, India, and Zimbabwe.

HIV Recency Surveillance in Malawi

The International Training and Education Center for Health (I-TECH), in collaboration with the Malawian Ministry of Health (MOH) and the Centers for Disease Control and Prevention, began implementing recent HIV infection surveillance in April 2019. The project aims to establish a surveillance system among persons newly diagnosed with HIV infection by integrating point-of-care testing for recent infection into routine HIV testing services (HTS). A rapid test for recent infection is given to consenting clients 13-years-and-older who screen HIV positive within routine HTS across participating health facilities. Between April 2019-2020, I-TECH and MOH activated 485 testing points at 155 facilities in Malawi. All 155 facilities implemented recent HIV infection surveillance and reported data. The project has reached 11 of 28 districts to date.

These data allow the detection and characterization of recent HIV infection among newly diagnosed individuals and identify geographic areas associated with recent HIV-1 infection to inform geographic prioritization of HIV prevention and treatment strategies. The project has demonstrated high uptake and allowed characterization of recent infections according to socio-demographic and geographic factors. PEPFAR implementers in Malawi will collaborate with MOH to further investigate the reasons for high recent infection prevalence in identified clusters. Based on the findings of these responses, Malawi may focus on interventions such as youth-focused programs that aim to limit HIV acquisition and transmission among young people.

Global Health Security Agenda in Kenya

I-TECH Kenya’s Global Health Security Agenda (GHSA)-funded programs aim to advance the GHSA goals of preventing , detecting, and responding to disease threats to health security.

For the past 8 years, I-TECH Kenya has had a cooperative agreement with US Centers for Disease Control and Prevention (CDC) to work closely with the Kenya Ministry of Health (MOH) on multiple projects related to health security. The key objectives of these activities are preventing and reducing the likelihood of disease outbreaks, improving the efficiency and accuracy of the detection of communicable diseases, strengthening surveillance capacity and national and county levels for a rapid and effective response, enhancing Infection Prevention and Control (IPC) practices to prevent the emergence and spread of pathogens and antimicrobial resistant bacteria.

Prevention

Use IPC practices to combat antimicrobial resistance (AMR) and other microbial threats:

  • Building capacity for IPC in health care facilities is a critical part of disease outbreak and AMR preparedness and prevention. In Kenya, I-TECH has partners with the CDC National Center for Emerging and Zoonotic Infectious Disease and Kenya MOH to support two model hospitals in developing capacity for quality improvement measures for strengthening evidence-based IPC practices, infrastructure, and tools including hand hygiene, waste management, injection safety, surgical site infections, and antimicrobial stewardship. As part of this IPC work, I-TECH created and piloted e-learning modules for IPC. The modules aim to build clinical skills and technical knowledge in infection prevention and control and antimicrobial stewardship among health care workers in low-resource settings, and have now been adopted by WHO.
  • With the onset of the COVID-19 pandemic, I-TECH Kenya was able to play a leadership role in the country in assessing and improving facility readiness at the national and local level to handle COVID-19 cases and maintain the health care workforce.
  • Current IPC activity is focused on surveillance for surgical site infections, an important cause of hospital acquired infections (HAIs).

Disease Prevention through Immunization Program Strengthening:

  • I-TECH collaborated with the Kenya MOH, CDC Global Health Protection Division, and the CDC Global Immunization Division, to build and roll out an online mobile platform for capturing immunization data at the point of care.

Detection

Laboratory Information Systems Strengthening:

  • In Kenya, I-TECH collaborated with the MOH and National Public Health Laboratory Services to enhance and strengthen laboratory information systems at the facility and national levels to improve timeliness and efficiency of testing and reporting results, specifically for AMR testing.

Response

Disease Surveillance and Response:

  • I-TECH supports the Kenya MOH Surveillance Unit in the rollout of trainings for health care workers to routinely and consistently use the real-time surveillance reporting system in Kenya.